Aim: To examine the association of serum lipids, lipid ratios with Chronic\nKidney Disease (CKD) in a Chinese population. Methods: Data were drawn from a\ncross-sectional survey in China. CKD was defined as estimated glomerular filtration rate\n(eGFR) < 60 mL/min/1.73m2 or albuminuria-to-creatinine ratio (ACR) > 30 mg/g.\nMultivariable logistic regressions and multivariate regression models were used. Serum\nlipids and lipid ratios included total cholesterol (TC), triglyceride (TG), low-density\nlipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C),\nTG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio. Results: In men, only\nlogarithm-transformed (log) TG was associated with CKD. The odds ratio (every SD\nincrement) was 1.39 (95% CI 1.03ââ?¬â??1.87, P = 0.03). In women, none of the serum lipids\nand lipid ratios was associated with CKD. Using multivariate regression models, it was shown that log TG and log TG/HDL-C were negatively correlated with eGFR (P < 0.05) in\nmen and LDL-C and log LDL-C/HDL-C ratio were correlated with ACR in men. In female\nsubjects, serum TC, log TG, log TG/HDL-C and log TC/HDL-C were negatively\ncorrelated with eGFR (P < 0.05). All of serum lipid profiles and lipid related ratio were not\ncorrelated with ACR in women. Conclusion: Serum TG is the only suitable predictor for\nCKD in men. However, in women, none of serum lipids and lipid ratio can be used as a\npredictor for CKD. Log TG and log TG/HDL-C are negatively correlated with eGFR in\nboth genders.
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